This technology is a non-toxic, biodegradable adhesive that allows bonding on wet surfaces, sealing of porous surfaces, and encapsulation of small molecules for controlled release devices. It is formulated with liquid polycaprolactone, a bioresorbable polymer, that has been exploited for production of polyurethane adhesives, medical devices, and drug delivery systems. The adhesive is hydrophobic, VOC-free, and is liquid at room temperature, and contains no toxic free radical initiators, hardeners, or other environmentally unfriendly ingredients. Upon activation by a simple hand-held UV LED, the liquid adhesive transitions into a cross-linked, expanding biorubber that non-specifically adheres to almost any surface. By exploiting carbene-crosslinking chemistry, it avoids the limitations associated with acrylates, epoxies, and urethane resins.
This technology is currently being explored for tissue adhesives, medical coatings, controlled-release encapsulants, and cosmetics.
Technology Features, Specifications and Advantages
This technology has the following features:
- Liquid phase at ambient temperatures with apparent viscosities under 1 Pa.s (1,000 cP), requires no dilution in aqueous or organic solvents – in the pure form, it flows easily via syringe or other liquid applicators.
- Available in a range of viscosities and cured material properties – cured elasticity can be tuned precisely for application specific properties due to the flexibility of the synthetic methodology. The synthetic methodology allows a scalable yield production, from laboratory batch production to continuous reactor-scale production.
- Naturally hydrophobic material that prevents water infiltration into the polymer matrix – allows long-term shelf storage of 12 months or greater at ambient conditions.
- Can act as water impenetrable sealants and coatings on both dry and wet surfaces –can be modified to be both aqueous porous and non-porous with pore-forming additives.
- Unique formulations allow temporary reduction of adhesive fouling caused by surface water-hydration – the amount of surface water-hydration is reduced, after 10 seconds, upon contact with wet substrates. Subsequent UV-LED curing allows increased substrate bonding.
- The inclusion of polycaprolactone precursors allows linear and branched polycaprolactones to be dissolved – formulate unique composites, for pre- and post-cured adhesives, with tunable chemical and mechanical properties.
- Adhesive curing is activated through UV-A irradiation over a wide range of intensities – enables partial curing to control viscosity (sealants) and end-stage material properties.
- Allows bonding on nearly all substrates, including thermo-labile, flexible, or hydrated surfaces.
- Tissue adhesives
- Medical coatings
- Biosensor implants
- Topical skin therapies
- Drug depots
- Biologics encapsulation
- Dental restorations
- Minimally invasive surgeries
- Soft tissue sealants
- Plastic surgery fillers
- Green adhesives
- Non-fouling surfaces
- 3D cell culture
- Multi-purpose sealants
- Temporary tattoos/skin explants
- Controlled chemical release
- Aquarium cements
- Expanding fillers
- Veterinarian products
Widely customisable biopolymer that is rapidly tailored for unique and unmet applications.